A Note about proving non-Γ\Gamma under a finite non-microstates free Fisher information Assumption

We prove that if $X_{1},...,X_{n} (n >1)$ are selfadjoints in a $W^{*}$-probability space with finite non-microstates free Fisher information, then the von Neumann algebra $W^{*}(X_{1},...,X_{n})$ they generate doesn't have property $\Gamma$ (especially is not amenable). This is an analog of a well-known result of Voiculescu for microstates free entropy. We also prove factoriality under finite non-microstates entropy.Comment: 12 pages; New results with similar techniques; cf. abstracts for detail

Orientation and experience in the perception of form: A study with the arizona whale-kangaroo

When subjects are presented with the Arizona whale-kangaroo, an ambiguous figure, perception of the whale is more common than perception of the kangaroo. However, this difference is smaller in Australian than American subjects. Perception of the kangaroo is more orientation dependent than perception of the whale, which is perceived at all orientations of the stimulus. Together with the difference between subject populations, this effect reveals an influence of past experience on the perception of this new ambiguous figure. Perception of the whale versus the kangaroo differs in both reconstrual of parts and realignment of the object-centered reference frame. Observers report reference frame reconstruals before reference frame reversals, shedding light on the organization of object memory

Gluon Fragmentation into 3PJ^3P_J Quarkonium

The functions of the gluon fragmentation into $^3P_J$ quarkonium are calculated to order $\alpha_s^2$. With the recent progress in analysing quarkonium systems in QCD we show explicitly how the socalled divergence in the limit of the zero-binding energy, which is related to $P$-wave quarkonia, is treated correctly in the case of fragmentation functions. The obtained fragmentation functions satisfy explicitly at the order of $\alpha_s^2$ the Altarelli-Parisi equation and when $z\rightarrow 0$ they behave as $z^{-1}$ as expected. Some comments on the previous results are made.Comment: Type-errors in the text and equations are eliminated. Several sentences are added in Sect.4. The file is compressed and uuencoded (E-Mail contact [email protected]

Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice

<p>Abstract</p> <p>Background</p> <p>The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system. We hypothesized that primary cilial dysfunction might play a role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), and as a first step, report on the prevalence of primary cilial markers on cultured motor neurons from the lumbar spinal cord of embryonic wildtype (WT) and transgenic G93A SOD1 mice, and on motor neurons in situ in the lumbar spinal cord.</p> <p>Results</p> <p>At 7 days in culture there is no difference in the proportion of G93A SOD1 and WT motor neurons staining for the cilial marker ACIII. However, at 21 days there is a large relative drop in the proportion of ciliated G93A SOD1 motor neurons. In situ, at 40 days there was a slight relative drop in the proportion of ciliated motor neurons in G93A SOD1 mice. At 98 days of age there was no change in motor neuron ciliation in WT mice, but there was motor neuron loss and a large reduction in the proportion of surviving motor neurons bearing a primary cilium in G93A SOD1 mice.</p> <p>Conclusions</p> <p>In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium.</p

Neratinib + fulvestrant + trastuzumab for HR-positive, HER2-negative, HER2-mutant metastatic breast cancer: Outcomes and biomarker analysis from the SUMMIT trial

BACKGROUND: HER2 mutations are targetable alterations in patients with hormone receptor-positive (HR+) metastatic breast cancer (MBC). In the SUMMIT basket study, patients with HER2-mutant MBC received neratinib monotherapy, neratinib + fulvestrant, or neratinib + fulvestrant + trastuzumab (N + F + T). We report results from 71 patients with HR+, HER2-mutant MBC, including 21 (seven in each arm) from a randomized substudy of fulvestrant versus fulvestrant + trastuzumab (F + T) versus N + F + T. PATIENTS AND METHODS: Patients with HR+ HER2-negative MBC with activating HER2 mutation(s) and prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy received N + F + T (oral neratinib 240 mg/day with loperamide prophylaxis, intramuscular fulvestrant 500 mg on days 1, 15, and 29 of cycle 1 then q4w, intravenous trastuzumab 8 mg/kg then 6 mg/kg q3w) or F + T or fulvestrant alone. Those whose disease progressed on F + T or fulvestrant could cross-over to N + F + T. Efficacy endpoints included investigator-assessed objective response rate (ORR), clinical benefit rate (RECIST v1.1), duration of response, and progression-free survival (PFS). Plasma and/or formalin-fixed paraffin-embedded tissue samples were collected at baseline; plasma was collected during and at end of treatment. Extracted DNA was analyzed by next-generation sequencing. RESULTS: ORR for 57 N + F + T-treated patients was 39% [95% confidence interval (CI) 26% to 52%); median PFS was 8.3 months (95% CI 6.0-15.1 months). No responses occurred in fulvestrant- or F + T-treated patients; responses in patients crossing over to N + F + T supported the requirement for neratinib in the triplet. Responses were observed in patients with ductal and lobular histology, 1 or ≥1 HER2 mutations, and co-occurring HER3 mutations. Longitudinal circulating tumor DNA sequencing revealed acquisition of additional HER2 alterations, and mutations in genes including PIK3CA, enabling further precision targeting and possible re-response. CONCLUSIONS: The benefit of N + F + T for HR+ HER2-mutant MBC after progression on CDK4/6is is clinically meaningful and, based on this study, N + F + T has been included in the National Comprehensive Cancer Network treatment guidelines. SUMMIT has improved our understanding of the translational implications of targeting HER2 mutations with neratinib-based therapy

Fractional quantum Hall effect at the filling factor ν=5/2\nu=5/2

The fractional quantum Hall (FQH) effect at the filling factor $\nu=5/2$ was discovered in GaAs heterostructures more than 35 years ago. Various topological orders have been proposed as possible candidates to describe this FQH state. Some of them possess non-Abelian anyon excitations, an entirely new type of quasiparticle with fascinating properties. If observed, non-Abelian anyons could offer fundamental building blocks of a topological quantum computer. Nevertheless, the nature of the FQH state at $\nu=5/2$ is still under debate. In this chapter, we provide an overview of the theoretical background, numerical results, and experimental measurements pertaining to this special FQH state. Furthermore, we review some recent developments and their possible interpretations. Possible future directions toward resolving the nature of the $5/2$ state are also discussed.Comment: Updated version; A chapter for Encyclopedia of Condensed Matter Physics, 2nd edition (Elsevier

The Drinfel'd twisted XYZ model

We construct a factorizing Drinfel'd twist for a face type model equivalent to the XYZ model. Completely symmetric expressions for the operators of the monodromy matrix are obtained.Comment: 15 pages, 4 figures, second preprint no. added, reference [14] added, typos correcte

Production of four-quark states with double heavy quarks at LHC

We study the hadronic production of four-quark states with double heavy quarks and double light antiquarks at LHC. The production mechanism is that a color anti-triplet diquark cluster consisting of double heavy quarks is formed first from the produced double heavy quark-antiquark pairs via $gg$ fusion hard process, followed by the fragmentation of the diquark cluster into a four-quark (tetraquark) state. Predictions for the production cross sections and their differential distributions are presented. Our results show that it is quite promising to discover these tetraquark states in LHC experiments both for large number events and for their unique signatures in detectors.Comment: 17 pages,8 figure